pasteurella multocida toxin

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Pasteurella multocida Active Pasteurella multocida toxin (full length) (DAG-P2722) This product is for research use only and is not intended for diagnostic…
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Pasteurella multocida Active Pasteurella multocida toxin (full length) (DAG-P2722) This product is for research use only and is not intended for diagnostic use.PRODUCT INFORMATION Product OverviewActive Pasteurella multocida toxin full length proteinAntigen DescriptionPasteurella multocida toxin (PMT) is produced by a gram-negative bacillus, Pasteurella multocida. PMT activates the Gq and G12/13 dependent signaling pathways. Gq and G12/13 are alpha subunits of the GTP trimer bound protein of animal cells. It does not activate the G11 dependent pathway although G11 is similar to Gq. This toxin binds to an unidentified receptor and then is introduced into the cells by endocytosis and starts to function then. Therefore it does not function on cells without the receptor or defective in the endocytosis pathway.NatureRecombinantExpression SystemE. coliSpeciesPasteurella multocidaPurity> 90 % by SDS-PAGE.ConjugateUnconjugatedApplicationsSDS-PAGE Cellular activity WB ELISACellular LocalizationCytoplasmicBio-activityInduction of aggregation of Swiss 3T3 cells by incubation with PMT.FormatLiquidBufferPreservative: None Constituents: 50% Glycerol, 0.1M Sodium chloride, 5mM Tris HCl, pH 7.5StorageStore at -20°C. Stable for 12 months at -20°C Preservative: None Constituents: 50% Glycerol, 0.1M Sodium chloride, 5mM Tris HCl, pH 7.5 This product is an active protein and may elicit a biological response in vivo, handle with caution.BACKGROUND IntroductionPasteurella is a genus of Gram-negative, facultatively anaerobic bacteria. Pasteurella species45-1 Ramsey Road, Shirley, NY 11967, USA Tel: 1-631-624-4882 Fax: 1-631-938-8221Email: info@creative-diagnostics.com 1© Creative Diagnostics All Rights Reservedare non-motile and pleomorphic. Most species are catalase-positive and oxidase-positive. KeywordsDermonecrotic toxin; DNT; Mitogenic toxin; PMT; ToxA; P. multocida toxin; Pasteurella multocida toxin45-1 Ramsey Road, Shirley, NY 11967, USA Tel: 1-631-624-4882 Fax: 1-631-938-8221Email: info@creative-diagnostics.com 2Š Creative Diagnostics All Rights Reserved
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